Genome-wide analysis identified candidate variants and genes associated with heat stress adaptation in Egyptian sheep breeds

cg.contactadelmaboulnaga@gmail.comen_US
cg.contributor.centerInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.contributor.centerAgricultural Genetic Engineering Research Institute - AGERIen_US
cg.contributor.centerAgricultural Research Center, Animal Production Research Institute - ARC - APRIen_US
cg.contributor.centerMohammed VI Polytechnic University - UM6Pen_US
cg.contributor.crpResilient Agrifood Systems - RAFSen_US
cg.contributor.funderThe French Agricultural Research Center for International Development - CIRADen_US
cg.contributor.funderAgence Nationale de la Recherche - ANRen_US
cg.contributor.initiativeSustainable Animal Productivityen_US
cg.contributor.project-lead-instituteInternational Center for Agricultural Research in the Dry Areas - ICARDAen_US
cg.coverage.countryEGen_US
cg.coverage.regionNorthern Africaen_US
cg.creator.idHamwieh, Aladdin: 0000-0001-6060-5560en_US
cg.identifier.doihttps://dx.doi.org/10.5281/zenodo.6371316en_US
cg.isijournalISI Journalen_US
cg.issn1664-8021en_US
cg.journalFrontiers in Geneticsen_US
cg.subject.actionAreaResilient Agrifood Systemsen_US
cg.subject.agrovocsheepen_US
cg.subject.agrovocheat toleranceen_US
cg.subject.agrovocegypten_US
cg.subject.agrovocgwasen_US
cg.subject.agrovocsnp genotypingen_US
cg.subject.agrovocgoal 13 climate actionen_US
cg.subject.agrovocsheepen_US
cg.subject.impactAreaClimate adaptation and mitigationen_US
cg.subject.sdgSDG 13 - Climate actionen_US
dc.contributorM.Alsamman, Alsammanen_US
dc.contributorEl Allali, Achrafen_US
dc.contributorElshafie, M.H.en_US
dc.contributorAbdelal, Ehab S.en_US
dc.contributorAbdelkhalek, Tarek M.en_US
dc.contributorAbdelsabour, Taha Hen_US
dc.contributorMohamed, Layaly G.en_US
dc.contributorHamwieh, Aladdinen_US
dc.creatorAdel M. Aboul-Naga, Adelen_US
dc.date.accessioned2023-01-04T20:48:35Z
dc.date.available2023-01-04T20:48:35Z
dc.description.abstractHeat stress caused by climatic changes is one of the most significant stresses on livestock in hot and dry areas. It has particularly adverse effects on the ability of the breed to maintain homeothermy. Developing countries are advised to protect and prepare their animal resources in the face of potential threats such as climate change. The current study was conducted in Egypt’s three hot and dry agro-ecological zones. Three local sheep breeds (Saidi, Wahati, and Barki) were studied with a total of 206 ewes. The animals were exercised under natural heat stress. The heat tolerance index of the animals was calculated to identify animals with high and low heat tolerance based on their response to meteorological and physiological parameters. Genomic variation in these breeds was assessed using 64,756 single nucleotide polymorphic markers (SNPs). From the perspective of comparative adaptability to harsh conditions, our objective was to investigate the genomic structure that might control the adaptability of local sheep breeds to environmental stress under hot and dry conditions. In addition, indices of population structure and diversity of local breeds were examined. Measures of genetic diversity showed a significant influence of breed and location on populations. The standardized index of association (rbarD) ranged from 0.0012 (Dakhla) to 0.026 (Assuit), while for the breed, they ranged from 0.004 (Wahati) to 0.0103 (Saidi). The index of association analysis (Ia) ranged from 1.42 (Dakhla) to 35.88 (Assuit) by location and from 6.58 (Wahati) to 15.36 (Saidi) by breed. The most significant SNPs associated with heat tolerance were found in the MYO5A, PRKG1, GSTCD, and RTN1 genes (p ≤ 0.0001). MYO5A produces a protein widely distributed in the melanin-producing neural crest of the skin. Genetic association between genetic and phenotypic variations showed that OAR1_18300122.1, located in ST3GAL3, had the greatest positive effect on heat tolerance. Genome-wide association analysis identified SNPs associated with heat tolerance in the PLCB1, STEAP3, KSR2, UNC13C, PEBP4, and GPAT2 genes.en_US
dc.formatPDFen_US
dc.identifierhttps://mel.cgiar.org/reporting/downloadmelspace/hash/88f879a2a8fccb18fc960e580fad521f/v/c577300597a7aa685c7f8cefe4f0f191en_US
dc.identifier.citationAdel Adel M. Aboul-Naga, Alsamman M. Alsamman, Achraf El Allali, M. H. Elshafie, Ehab S. Abdelal, Tarek M. Abdelkhalek, Taha H Abdelsabour, Layaly G. Mohamed, Aladdin Hamwieh. (3/10/2022). Genome-wide analysis identified candidate variants and genes associated with heat stress adaptation in Egyptian sheep breeds. Frontiers in Genetics.en_US
dc.identifier.statusOpen accessen_US
dc.identifier.urihttps://hdl.handle.net/20.500.11766/67869
dc.languageenen_US
dc.publisherFrontiers Mediaen_US
dc.rightsCC-BY-4.0en_US
dc.sourceFrontiers in Genetics;(2022)en_US
dc.subjectsheep breeden_US
dc.subjectdry areasen_US
dc.subjectclimate adaptation and mitigationen_US
dc.titleGenome-wide analysis identified candidate variants and genes associated with heat stress adaptation in Egyptian sheep breedsen_US
dc.typeJournal Articleen_US
dcterms.available2022-10-03en_US
mel.impact-factor4.772en_US

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