Optimal allocation of patients in titration to fixed dose trials

Sudhir Gupta, Balakrishna Hosmane, Murari Singh, Rajendra Singh. (1/8/2002). Optimal allocation of patients in titration to fixed dose trials. Journal of Statistical Planning and Inference, 106 (1-2), pp. 215-223.

Abstract

Optimal allocations of patients to different arms of a fixed dose titration trial for estimating the dose–response relationship are provided. Optimal sample sizes are derived for the case where the linearizing transformation is log(dose). Optimal sample sizes for predicting the response are also derived. For equi-spaced dose levels on the log scale, the determination of optimal doses is also considered.